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All Nurse Practitioner Jobs· 42 JobsGeneral Physician Assistant· 24 JobsNP - Acute Care· 4 JobsNP - Cardiac Surgery· 2 JobsNP - Cardiology· 1 JobNP - Critical Care· 1 JobNP - Emergency Medicine· 6 JobsNP - Family Medicine· 12 JobsNP - General Surgery· 2 JobsNP - Geriatric Medicine· 2 JobsNP - Hospitalist· 3 Jobs
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Nurse Practitioner Jobs in South Carolina
Showing 39 nurse practitioner opportunities in South Carolina
38 in cities, 1 statewide
Nocturnist ICU Advanced Practice Clinician in Rock Hill, SC
General Nurse Practitioner
Rock Hill, South Carolina
TeamHealth Piedmont Healthcare System
Full-time
Permanent
In-person
TeamHealth is seeking a full-time nocturnist ICU nurse practitioner or physician assistant to join our critical care team at Piedmont Medical Center in Rock Hill, South Carolina. This opportunity is ideal for an advanced practice clinician who enjoys the pace and complexity of critical care and prefers working nights. Prior experience practicing as an NP or PA in an ICU or critical care setting is strongly preferred. What You Can Expect • Full-time nocturnist position • Benefits for eligible full-time clinicians • ICU-focused clinical pr...
Hospitalist Advanced Practice Clinician in Rock Hill, SC
General Nurse Practitioner
Rock Hill, South Carolina
TeamHealth Piedmont Healthcare System
Full-time
Permanent
In-person
TeamHealth is seeking a nurse practitioner or physician assistant to join our hospitalist team at Piedmont Medical Center in Rock Hill, South Carolina! This is a full-time night shift (7pm-7am) position that offers a flexible block 7-on/7-off schedule. About Piedmont Medical Center • 288-bed facility • Closed ICU • EMR: Cerner • No solo APC coverage requiredPosition Details • Full-time night shift position: 7pm-7am • 7 days on/7 days off, block schedule • Primary responsibilities: floor calls, admissions, rounding, and discharges • APC w...
Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Myrtle Beach, South Carolina
CareNow
Full-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking a Board-Certified Full-Time Physician Assistant or Nurse Practitioner to join our Myrtle Beach, SC Market, more specifically providing coverage out of our Conway and surrounding clinic locations. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • Ability t...
Full-Scope Certified Nurse Midwife - Lakefront South Carolina - Florence area
General Nurse Practitioner
Hartsville, South Carolina
Inspire Healthcare
Full-time
Permanent
In-person
• Certified Nurse Midwife • Hospital-employed established practice • Full-time, in-person role • Care in office, hospital, and labor and delivery settings • Experienced and team-oriented candidate required • Level I nursery • 1:5 call • 24/7 anesthesia coverage for OB • Dedicated triage rooms within the unit • Pediatric coverage available for emergency C-sections • Full benefits • Relocation assistance • 166-bed facility • Population of about 70,000 in the county and 120,000 in the catchment area • Nearby recreation includes the Pee Dee ...
Emergency Medicine Advanced Practice Clinician in Columbia, SC
General Nurse Practitioner
Columbia, South Carolina
TeamHealth MUSC Health - Garners Ferry Freestanding Emergency Department
Full-time
Permanent
In-person
TeamHealth is currently seeking experienced nurse practitioners and physician assistants to join our team at the new MUSC Garners Ferry Freestanding Emergency Department in Columbia, South Carolina. Ideal candidates will have prior emergency medicine or urgent care experience as a PA or NP, current South Carolina license, DEA as well as current ACLS/PALS certifications. Apply today to learn more! California Applicant Privacy Act: https://www.teamhealth.com/california-applicant-privacy-notice/ - Full benefits - Paid time off - Paid holida...
Emergency Medicine Advanced Practice Clinician in Florence, SC
General Nurse Practitioner
Florence, South Carolina
TeamHealth MUSC Health ED and Urgent Care - Florence
Full-time
Permanent
In-person
MUSC and TeamHealth are expanding their partnership in the Pee Dee Region of South Carolina to open a combined urgent care and free standing emergency department to serve the community. Join us as an emergency medicine nurse practitioner or physician assistant to provide high quality care in Florence and the surrounding areas. Ideal candidates will have prior EM experience as a PA or NP, a current South Carolina license, and DEA as well as ACLS/PALS certifications. Apply today to learn more. California Applicant Privacy Act: https://www....
Orthopaedic Surgery Advanced Practice Provider
General Nurse Practitioner
Myrtle Beach, South Carolina
Grand Strand Medical Center
Full-time
Permanent
In-person
Description Specialization: Orthopaedic Surgery Job Summary: Recruiting a highly motivated physician assistant or nurse practitioner to join our Orthopaedic Surgery team at Grand Strand Medical Center in Myrtle Beach, South Carolina. Job responsibilities include: • Preoperative assessment, intra-operative assistance, and postoperative care in the hospital • Preoperative evaluation, postoperative followup, and on-going care in the clinical setting • Daily rounds, document notes, writing new orders and discharge instructions • Consults in ...
Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Charleston, South Carolina
CareNow
Full-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking a full-time, board-certified physician assistant or nurse practitioner to join our Charleston, SC Market. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • Ability to perform first reads on x-rays • Skills to perform patient treatment procedures for most ...
PRN Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Charleston, South Carolina
CareNow
PRN
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking board certified PRN physician assistants or nurse practitioners to join our Charleston, SC Market. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • Ability to perform first reads on x-rays • Skills to perform patient treatment procedures for most acute i...
Experienced APP Needed at Myrtle Beach
General Nurse Practitioner
Myrtle Beach, South Carolina
Curare Physician Recruiting
Full-time
Permanent
In-person
Myrtle Beach hospital is seeking an skilled Cardiothoracic Surgery APP with EVH experience to join their team of 3 Cardiothoracic Surgeons. Located in the heart of the "Grand Strand," this growing metropolitan area has been repeatedly recognized as one of the top retirement and tourist destinations with easy access to the ocean, golf, shopping, entertainment, boating, and dining. Must have 2 or more years' experience with all routine heart surgery procedures and thoracic procedures. Possess understanding of clinic follow ups and post op ...
Head & Neck - Lead Speech Language Pathologist
General Nurse Practitioner
Charleston, South Carolina
HCA Healthcare Trident Hospital
Full-time
Permanent
In-person
Description Specialization: Pathology Selective Job Summary: HCA Healthcare Trident Hospital is seeking a Speech Language Pathologist to lead our Head & Neck Specialists SLP program in Charleston, South Carolina. Sarah Cannon Cancer Network The Sarah Cannon Cancer Network-Head and Neck Specialists team at HCA Healthcare Trident Hospital in Charleston SC is seeking an experienced speech-language pathologist specializing in Head and Neck Oncology to join our comprehensive head and neck multidisciplinary team. This individiaul will work wit...
PRN Critical Care Advanced Practice Provider
General Nurse Practitioner
Charleston, South Carolina
HCA Healthcare Trident Hospital
PRN
Permanent
In-person
Description Specialization: Acute Care Job Summary: ICC (Intensive Care Consortium) is seeking a PRN experienced critical care nurse practitioner or physician assistant to join Trident Medical Center in Charleston, South Carolina. Qualified Candidates: • Acute care certified NP or licensed PA • ICU experience highly desired • APP providers must be proficient with, and credentialed to perform routine Critical Care procedures including central and arterial line placement, intubations, and management of mechanical ventilation • Ability to w...
Cardiothoracic Surgery Advanced Practice Provider
General Nurse Practitioner
Myrtle Beach, South Carolina
Grand Strand Medical Center
Full-time
Permanent
In-person
Description Specialization: Cardiothoracic Surgery Job Summary: Leading Heart Program in Myrtle Beach, South Carolina is seeking a skilled CT-APP with EVH experience to join in assisting their 3 employed cardiothoracic surgeons and 3 APPs at Grand Strand Medical Center. Join a Growing Cardiothoracic Surgery Program: We are seeking an experienced and highly motivated Cardiothoracic APP (Physician Assistant or Acute Care NP) to join our expanding cardiothoracic surgery program. The position offers a balanced blend of operative first assist...
Nurse Practitioner Job Opportunity in South Carolina
General Nurse Practitioner
Columbia, South Carolina
Healthwaze
Full-time
Permanent
In-person
We are seeking a skilled Nurse Practitioner for a Monday-Friday (8 AM - 5 PM) position in Columbia, SC. Work alongside a cardiologist providing high-quality patient care – no procedures required. Responsibilities: • Daily rounds with a physician • Exceptional patient care (no procedures). • Consistent weekday schedule (no nights, weekends, or call). Benefits: • Competitive Salary • Health Insurance • Paid time off • Paid Malpractice • Collaborative and supportive team. Apply now to join our dedicated team in South Carolina! ...
Living and Working in South Carolina
Key information for nurse practitioners considering jobs in South Carolina.
Cost of living
94 / 100
About 6% below the national average.
Source: BEA | Data as of: 9/28/2026
Median home value
$259,000
Well below the U.S. median.
Source: Census ACS | Data as of: 9/28/2026
Property tax
~0.5%
Well below the national average. About $1,251/yr on a median home.
Source: Census ACS | Data as of: 9/28/2026
State income tax
5.21% Top rate
South Carolina has a 5.21% top marginal state income tax rate.
Source: South Carolina Department of Revenue | Data as of: 9/29/2026
Health Professional Shortage Designations in South Carolina
Primary Care:
20 counties (43%) have countywide shortage designations. 25 counties (54%) have other HPSA designations that apply to part of a county or to specific underserved populations.
Mental Health:
40 counties (87%) have countywide shortage designations. 4 counties (9%) have other HPSA designations that apply to part of a county or to specific underserved populations.
Dental Health:
15 counties (33%) have countywide shortage designations. 25 counties (54%) have other HPSA designations that apply to part of a county or to specific underserved populations.
- Eligible healthcare professionals at NHSC-approved sites may qualify for NHSC loan repayment. Eligibility varies by profession, specialty, HPSA type, and program requirements.
- HPSA status may vary by practice location. Verify a specific practice address with HRSA.
Source: HRSA | Data as of: 9/28/2026
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