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Nurse Practitioner Jobs in South Carolina
Showing 39 nurse practitioner opportunities in South Carolina
38 in cities, 1 statewide
Emergency Medicine Advanced Practice Clinician in Dillon, SC
General Nurse Practitioner
Dillon, South Carolina
TeamHealth McLeod Dillon Hospital
Full-time
Permanent
In-person
Provide high-quality patient care with TeamHealth in South Carolina. McLeod Dillon Hospital is seeking an experienced and motivated advanced practice clinician to join our growing emergency medicine team. This is an excellent opportunity for nurse practitioners or physician assistants looking to practice in a supportive environment while making a meaningful impact on the health of the local community. Who We're Looking For • NP or PA with prior EM and/or urgent care experience • Active South Carolina license • Current DEA registration • ...
Nurse Practitioner in Charleston, SC
General Nurse Practitioner
Charleston, South Carolina
TeamHealth Charleston Area Post-Acute Care Practice
Full-time
Permanent
In-person
Let us show you how you can have a successful career with the work/life balance to enjoy all the area has to offer. TeamHealth is seeking a quality-driven nurse practitioner or physician assistant to join our post-acute care team in Charleston, South Carolina. This is a full-time opportunity (4-5 days/week) rounding in a skilled nursing facility, with excellent support and training, autonomy, and earning potential. Compensation is fee for service with an estimated compensation range of $126,000 to $150,000 annually with no cap on product...
Nurse Practitioner in Columbia, SC
General Nurse Practitioner
Columbia, South Carolina
TeamHealth Columbia Area Post-Acute Care Practice
Full-time
Permanent
In-person
TeamHealth is seeking a quality-driven nurse practitioner or physician assistant to join our post-acute care team in Columbia, South Carolina. This is a full-time opportunity (4 days/week - 2 weekdays + Saturday and Sunday) rounding in skilled nursing facilities, with excellent support and training, autonomy, and earning potential. Compensation is fee for service with an estimated compensation range of $98,926 - $117,112 annually and no cap on productivity income potential. In this role, you'll provide high-quality care to a diverse pati...
Floating Family Medicine Nurse Practitioner or Physician Assistant - Abbeville, SC (Multi-Site)
General Nurse Practitioner
Abbeville, South Carolina
AAS Healthcare Staffing
Full-time
Permanent
In-person
$100K per year
We are hiring a Nurse Practitioner or Physician Assistant to serve as a floating family medicine provider across outpatient clinics in Abbeville, Greenwood, Laurens, McCormick, and Saluda counties, SC. The provider will deliver primary care services across the lifespan with emphasis on prevention, wellness, and chronic disease management. Responsibilities • Provide comprehensive primary care for patients of all ages, including assessment, diagnosis, treatment, chronic disease management, and preventive care. • Travel regularly to assigne...
Floating Family Medicine NP/PA - $100K, Travel Between Greenwood Area Clinics, Benefits
General Nurse Practitioner
Greenwood, South Carolina
AAS Healthcare Staffing
Full-time
Permanent
In-person
$100K per year
We’re looking for a compassionate, experienced Nurse Practitioner or Physician Assistant to join our Family Medicine team as a floating provider. In this role you’ll provide primary care across multiple outpatient sites in Abbeville, Greenwood, Laurens, McCormick, and Saluda counties, delivering patient-centered care that emphasizes prevention, wellness, and chronic disease management while building trusting relationships with patients and families. What you’ll do: • Deliver comprehensive primary care for patients across the lifespan. • ...
Family Medicine Floating Nurse Practitioner or Physician Assistant - Laurens, SC (Multi-Site)
General Nurse Practitioner
Laurens, South Carolina
AAS Healthcare Staffing
Full-time
Permanent
In-person
$100K per year
Seeking a Nurse Practitioner (NP) or Physician Assistant (PA) to serve as a floating family medicine provider supporting multiple outpatient clinics across Abbeville, Greenwood, Laurens, McCormick, and Saluda counties, SC. The provider will deliver patient-centered primary care with a focus on prevention and chronic disease management. Primary responsibilities • Provide comprehensive primary care across the lifespan (wellness, acute and chronic care). • Travel regularly between assigned family medicine sites within Abbeville, Greenwood, ...
Urgent Care NP/PA role available in the Myrtle Beach, SC area
General Nurse Practitioner
South Carolina, United States
GO Staffing
Full-time
Permanent
In-person
Great opportunity in the Myrtle Beach, SC for a Nurse Practitioner or Physician Assistant to work in the Urgent Care department of a multispecialty facility. • Board Certified Nurse Practitioner (NP) or Physician Assistant (PA) • Must have 1+ yrs exp in Urgent Care, ER, or Primary Care as NP/PA • Mon-Sun 8a-7p • Flexible on 3/12's or 4/10's • 30+ patients per shift • Collaborative physician support, exp clinical team, and dedicated nurse • No 2 days are the same - infections, lacerations, burns, sprains, strains, allergic reactions, occ ...
Emergency Medicine Advanced Practice Clinician in Manning, SC
General Nurse Practitioner
Manning, South Carolina
TeamHealth McLeod Health Clarendon
Full-time
Permanent
In-person
TeamHealth has a new opportunity in Central South Carolina! McLeod Health Clarendon is looking for a nurse practitioner or physician assistant to join our emergency medicine team. If you are a PA/NP with prior EM or urgent care experience, current South Carolina license, DEA as well as ACLS/PALS certifications, you're just right for this role. Apply today to learn more! California Applicant Privacy Act: https://www.teamhealth.com/california-applicant-privacy-notice/ - Full benefits - Paid time off - Paid holidays - Access to TeamHealth I...
Emergency Medicine Advanced Practice Clinician in Little River, SC
General Nurse Practitioner
Little River, South Carolina
TeamHealth Seacoast Medical Center
Full-time
Permanent
In-person
Ready to build your emergency medicine career where others come to vacation? Join our growing multi-facility team along South Carolina's renowned Grand Strand and enjoy the perfect blend of rewarding clinical practice and coastal living. TeamHealth is seeking an experienced nurse practitioner or physician assistant who is passionate about emergency medicine and thrives in a fast-paced, patient-centered environment. Whether you're looking for professional growth, schedule flexibility, or the opportunity to practice in a desirable beachsid...
Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Pawleys Island, South Carolina
CareNow
Full-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking a Board-Certified Full-Time Physician Assistant or Nurse Practitioner to join our Myrtle Beach, SC Market, more specifically providing coverage out of our Pawleys Island and surrounding clinic locations. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • A...
Part-Time Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Conway, South Carolina
CareNow
Part-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking a board-certified Part-Time physician assistant or nurse practitioner to join our Myrtle Beach, SC Market. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • Ability to perform first reads on x-rays • Skills to perform patient treatment procedures for most...
Part-Time Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Spartanburg, South Carolina
CareNow
Part-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking a board-certified Part-Time physician assistant or nurse practitioner to join our Columbia, SC Market, more specifically providing coverage out of our Spartanburg clinic location. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain North Carolina state medical licensure • Ability to perform first ...
Urgent Care Family Medicine Advanced Practice Provider
General Nurse Practitioner
Spartanburg, South Carolina
CareNow
Full-time
Permanent
In-person
Description Specialization: Urgent Care Urgent Care Emergency Medicine Urgent Care Family Medicine Urgent Care Internal Medicine Pediatrics Job Summary: CareNow Urgent Care is seeking board certified Full-Time physician assistants or nurse practitioners to join our Columbia, SC Market, more specifically providing coverage out of our Spartanburg clinic location. Qualified Candidates: • Comfortable seeing ages three months and up • Board certified • Has or willing to obtain South Carolina state medical licensure • Ability to perform first ...
Emergency Medicine Advanced Practice Clinician in Charleston, SC
General Nurse Practitioner
Charleston, South Carolina
TeamHealth
Full-time
Permanent
In-person
Be part of something new from the ground up! MUSC and Intuitive Health are expanding their partnership in South Carolina with the opening of a state-of-the-art combined freestanding emergency department and urgent care center in the growing West Ashley community in the Charleston area. This innovative model brings together the convenience of urgent care and the resources of emergency medicine under one roof, allowing clinicians to practice at the top of their license while delivering the right level of care to every patient. We are seeki...
Interventional Radiology PA opening in Hartsville, SC
General Nurse Practitioner
Hartsville, South Carolina
Archway Physician Recruitment
Full-time
Permanent
In-person
**Interventional Radiology PA opening in Hartsville, SC** Florence, SC 23m; Columbia, SC 69m We are seeking an experienced Interventional Radiology PA to join our growing radiology group team. * Must be able to do IR procedures **Compensation Package includes:** * Guaranteed comp + wRVU bonus * CME stipend and 3 days of CME time off * $10K Relocation * 25 days off annually * Strong benefits package * 401k * Sign on bonus * Student loan support Located midway between Charlotte and Myrtle Beach, the community provides a rich lifestyle full...
Physician Assistant - Vascular Surgery Need in SC
General Nurse Practitioner
Fort Mill, South Carolina
Archway Physician Recruitment
Full-time
Permanent
In-person
Physician Assistant - Vascular Surgery Need in SC Located in Fort Mill 25 from Charlotte, NC Full-Time & Permanent Seeking a certified Physician Assistant to join Vascular Surgery group. - Full time position with duties split between First Assist and Inpatient responsibilities - Schedule: 4-10 hour days with 1:3 call (7 days a month) - EVH experience is highly preferred - Highly Competitive salary, call pay, and a comprehensive benefits package. Location: A vibrant, family-friendly community located just 15 minutes from Uptown Charlotte,...
Hospital Medicine Advanced Practice Clinician Fellowship in Myrtle Beach, SC
General Nurse Practitioner
Myrtle Beach, South Carolina
TeamHealth Grand Strand Medical Center
Full-time
Permanent
In-person
Are you a recent nurse practitioner or physician assistant graduate looking to launch your career in hospital medicine? TeamHealth is seeking motivated, ambitious, and highly skilled nurse practitioners and physician assistants to join our Hospital Medicine Advanced Practice Clinician Fellowship Program. This paid fellowship is designed to provide a comprehensive, immersive learning experience that prepares clinicians to enter the field of hospital medicine with confidence. We accept applications on an ongoing basis for fellowship cohort...
Cardiovascular Surgery Advanced Practice Provider
General Nurse Practitioner
Charleston, South Carolina
HCA Healthcare Trident Hospital
Full-time
Permanent
In-person
Description Specialization: Cardiovascular Surgery Job Summary: Leading Heart Program in Charleston, South Carolina is seeking a skilled CT-APP with EVH experience to join in assisting their 2 employed cardiothoracic surgeons and 3 APPs at HCA Healthcare Charleston. Join a Growing Cardiothoracic Surgery Program: We are seeking an experienced and highly motivated Cardiothoracic APP (Physician Assistant or Acute Care NP) to join our expanding cardiothoracic surgery program. The position offers a balanced blend of operative first assisting,...
Nurse Practitioner in Hilton Head, SC
General Nurse Practitioner
Hilton Head Island, South Carolina
TeamHealth Hilton Head Area Post-Acute Care Practice
Full-time
Permanent
In-person
TeamHealth is seeking a quality-driven nurse practitioner or physician assistant to join our post-acute care team in Hilton Head, South Carolina. This is a part-time opportunity (2 days/week) rounding in skilled nursing facilities, with excellent support and training, autonomy, and earning potential. Compensation is fee for service with an estimated compensation range of $26,808 - $32,170 annually and no cap on productivity income potential. In this role, you'll provide high-quality care to a diverse patient population, collaborate with ...
Neonatal Nurse Practitioner - Per Diem
General Nurse Practitioner
Florence, South Carolina
Pediatrix & Obstetrix
PRN
Permanent
In-person
Immediate opportunity for a per diem, certified NNP to join our busy practice at Mcleod Regional Medical Center in Florence, South Carolina. • McLeod Regional Medical Center is one of five regional perinatal centers for northeastern SC that provides the highest level of care and technology for high risk Moms and babies • The NNPs will provide 24 hour coverage in this busy Level-III NICU • 24 hour in house shifts • Current APRN national specialty certification • Minimum of a master’s degree • SC license required • Recent experience requir...
Neonatal Nurse Practitioner - Per Diem
General Nurse Practitioner
Spartanburg, South Carolina
Pediatrix & Obstetrix
PRN
Permanent
In-person
Per Diem NNP position in Spartanburg (SC)! Pediatrix Medical Group has an exciting opportunity for an experienced, certified Neonatal Nurse Practitioners (NNPs) to provider per diem coverage at Spartanburg Regional Medical Center.Neonatal Nurse Practitioner (NNP) Opportunity – Spartanburg Regional Medical CenterLocation: Spartanburg, South Carolina Position Type: Per Diem • Oversee a 35-bed Level-III NICU, providing comprehensive neonatal care including high-frequency ventilation and hypothermia therapy • Work alongside a team of experie...
Neonatal Nurse Practitioner - Per Diem
General Nurse Practitioner
Greenville, South Carolina
Pediatrix & Obstetrix
PRN
Permanent
In-person
Per Diem NNP opportunity in Greenville, SC! Nationally Recognized Health System! We have an exciting opportunity for a per diem, experienced, certified NNP to join our dedicated team of Neonatologist and NNPs at Prisma Health Greenville Memorial Hospital, in Greenville, SC. We are looking for an enthusiastic team-orientated individual, that is dedicated to providing excellent care for our smallest patients. Our practice is a robust Level-IIIb, 80-bed NICU with 1,000 annual admissions • We offer an attractive NNP schedule with both day an...
Neonatal Nurse Practitioner
General Nurse Practitioner
Greenville, South Carolina
Pediatrix & Obstetrix
Full-time
Permanent
In-person
Live in Beautiful Greenville, SC! Nationally Recognized Health System! New Competitive Salary! Sign-on and Relocation Bonuses Available! Ask us about potential tuition reimbursement assistance Neonatal Nurse Practitioner Opportunity – Prisma Health Greenville Memorial Hospital Greenville, South Carolina We are excited to offer an outstanding opportunity for an exceptional Neonatal Nurse Practitioner (NNP) to join our dedicated team of Neonatologists and NNPs at Prisma Health Greenville Memorial Hospital in Greenville, SC. We are seeking ...
Neonatal Nurse Practitioner
General Nurse Practitioner
Columbia, South Carolina
Pediatrix & Obstetrix
Full-time
Permanent
In-person
Enjoy an Active Lifestyle, Wonderful Weather and an Affordable Cost of Living! Ask us about potential tuition reimbursement assistance Exciting opportunity for an experienced NNP, or highly motivated recent graduate, to join our well-established practices of neonatologists and NNPs in Columbia, South Carolina. Our team provides newborn and neonatology services at Prisma Health Richland and Prisma Health Baptist. We are expanding our team to include full-time Neonatologist and NNP care at both locations. • Prisma Health Baptist Medical Ce...
Neonatal Nurse Practitioner
General Nurse Practitioner
Spartanburg, South Carolina
Pediatrix & Obstetrix
Full-time
Permanent
In-person
Elevate your nursing career in Spartanburg! Just a short drive to Greenville’s vibrant community! Ask us about potential tuition reimbursement assistanceNeonatal Nurse Practitioner (NNP) Opportunity – Spartanburg Regional Medical Center Location: Spartanburg, South Carolina Position Type: Full-Time We have an exciting opportunity for an exceptional Neonatal Nurse Practitioners (NNPs) to join our outstanding team of Neonatoligst at Spartanburg Regional Medical Center. About the Role • Oversee a 35-bed Level-III NICU, providing comprehensi...
Living and Working in South Carolina
Key information for nurse practitioners considering jobs in South Carolina.
Cost of living
94 / 100
About 6% below the national average.
Source: BEA | Data as of: 9/28/2026
Median home value
$259,000
Well below the U.S. median.
Source: Census ACS | Data as of: 9/28/2026
Property tax
~0.5%
Well below the national average. About $1,251/yr on a median home.
Source: Census ACS | Data as of: 9/28/2026
State income tax
5.21% Top rate
South Carolina has a 5.21% top marginal state income tax rate.
Source: South Carolina Department of Revenue | Data as of: 9/29/2026
Health Professional Shortage Designations in South Carolina
Primary Care:
20 counties (43%) have countywide shortage designations. 25 counties (54%) have other HPSA designations that apply to part of a county or to specific underserved populations.
Mental Health:
40 counties (87%) have countywide shortage designations. 4 counties (9%) have other HPSA designations that apply to part of a county or to specific underserved populations.
Dental Health:
15 counties (33%) have countywide shortage designations. 25 counties (54%) have other HPSA designations that apply to part of a county or to specific underserved populations.
- Eligible healthcare professionals at NHSC-approved sites may qualify for NHSC loan repayment. Eligibility varies by profession, specialty, HPSA type, and program requirements.
- HPSA status may vary by practice location. Verify a specific practice address with HRSA.
Source: HRSA | Data as of: 9/28/2026
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